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Post by the Scribe on Jun 29, 2019 11:48:23 GMT -5
Oh my god look at that food!! What did we miss?
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Post by the Scribe on Jun 29, 2019 11:47:30 GMT -5
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Post by the Scribe on Jun 29, 2019 11:46:54 GMT -5
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Post by the Scribe on Jun 29, 2019 11:46:18 GMT -5
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Post by the Scribe on Jun 29, 2019 11:45:51 GMT -5
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Post by the Scribe on Jun 29, 2019 11:45:18 GMT -5
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Post by the Scribe on Jun 29, 2019 11:44:55 GMT -5
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Post by the Scribe on Jun 29, 2019 11:44:24 GMT -5
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Post by the Scribe on Jun 29, 2019 11:43:08 GMT -5
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Post by the Scribe on Jun 29, 2019 11:38:33 GMT -5
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Post by the Scribe on Jun 29, 2019 11:37:49 GMT -5
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Post by the Scribe on Jun 29, 2019 11:37:20 GMT -5
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Post by the Scribe on Jun 29, 2019 11:36:51 GMT -5
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Post by the Scribe on Jun 29, 2019 11:36:15 GMT -5
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Post by the Scribe on Jun 29, 2019 11:34:08 GMT -5
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Post by the Scribe on Jun 29, 2019 11:33:02 GMT -5
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Post by the Scribe on Jun 29, 2019 6:50:37 GMT -5
C'MON GET HAPPY BIRTHDAY
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Post by the Scribe on Jun 29, 2019 6:36:33 GMT -5
not just for cancerPOLY MVAMore than 50 years ago, medical therapeutic approaches focused on metabolism. With the advent of genetics, a shift toward genomics occurred that has dominated the landscape of modern medicine. This gave us vast insight into the study of medicine and the human genome, however, it has not produced the answers or solutions that we had hoped for. Metabolism or better phrased, metabolic medicine, is now being revisited and showing considerable promise for our health. One approach is to target the process of cellular energy — this is metabolic and cellular power.
In a simple explanation, Poly-MVA is exactly what its name says. Poly meaning multiple, the MVA meaning Minerals, Vitamins, and Amino acids. This combination of a Lipoic Acid Complex with specific co-factors of minerals, vitamins, and amino acids targets, supports, maintains and improves the integrity of our mitochondria (the powerhouses of our cells) and can rescue our cells from damage. As a metabolic agent, it’s going to protect, correct, enhance our metabolic power to keep all cells healthy and support the body’s natural mechanisms against abnormal environments and poor health.
Lipoic Acid Mineral Complex (the unique LAMC complex inside of Poly-MVA) is what is called a redox molecule that facilitates energy charge transfer at the cellular level not only to protect and repair our DNA but more importantly to our Mitochondria, the power plant of the majority of our cells and the energy source for all cellular activity. (In basic scientific terms, a redox molecule means that it can accept an electrical charge and then donate that charge, which makes it an extremely effective cellular energy-transferring molecule.)
The power of LAMC is that it can effectively protect cells and then safely provide energy to them. Many years of research and clinical studies provide consistent and ongoing evidence that Poly-MVA can support gene repair (in genes damaged by disease and or radiation), support multiple therapies and cellular degeneration because of its mitochondrial up-regulation with an increase of oxygen.
Once inside our cells, Poly-MVA supports and increases energy production (ATP) via the Krebs cycle, its enzymes, and its normal oxygen pathways. This normal energy pathway gives all our cells a boost and increases cellular mitochondrial function while at the same time disrupting dysfunctional metabolism, particularly the metabolism of the (anaerobic) cancer cell that does not have the proper oxygen pathways. They are using glycolysis and non-oxygen pathways to create energy for survival and replication.
Quick Facts LAMC/Poly-MVA is a unique compound created through an innovative process whereby the mineral palladium is bound to alpha lipoic acid and Vitamin B1 (thiamine). When alpha lipoic acid, a unique and powerful antioxidant with multiple health benefits, is connected to an electrically charged mineral (palladium) and joined with thiamin (B1), the resulting complex is both water and fat soluble, dramatically increasing the entire body's absorption of Poly-MVA at the cellular level. With Vitamins B1, B2 and B12, specific trace minerals and amino acids, this unique complex and formulation create an amazing synergy, action, and function. It is designed to provide energy for the body's systems as well as protect cells from oxidation through its proprietary and patented formulation. Poly-MVA was formulated by Dr. Merrill Garnett, who has conducted research on the actions of DNA within normal and abnormal cells. Multiple studies have shown Poly-MVA's effectiveness in many different cell lines, with cellular support occurring in normal cells. The benefit from the increase in oxygen and ATP is support for normal cellular function in other cells. The alpha lipoic acid, B-1, and mineral are irreversibly bound together, resulting in a molecule that is both fat and water soluble (so it travels to all parts of the body) and significantly more effective than any individual ingredient. Poly-MVA has undergone extensive use and testing both orally and intravenously IV in various support roles of cancer, other degenerative diseases and as a daily preventative tonic, with a safety record of almost 20 years. Furthermore, Poly-MVA is a highly-effective free radical scavenger, yet it is more than that. Its ability to donate electrons to the mitochondria of the cell is critical to its benefits. In addition to cancer support, clinical research also continues to support its benefits in various applications including neurological support, support, stroke, TBI (traumatic brain injury), ischemia, hypertension, fatigue, and cardiovascular applications. This is because; following an interruption of blood flow to any tissue, there is a deprivation of oxygen and glucose. Providing an alternative energy source can maintain the integrity of the electron transport chain within the mitochondria and provide significant support for survival, repair, and regeneration. The LAMC complex and its ability to shuttle electrons to not only support and protect oxidized DNA while also going to the mitochondria (this is critical since mitochondrial health is a major concern during myocardial and neurological support, as well as in countless other health concerns were mitochondrial dysfunction plays a role). This product safely and effectively protects and supports cellular function. It is designed to provide energy for the compromised body systems by increasing cellular energy levels, thus increasing the charge density of DNA within the cell. This supports and increases normal cell function and works against cellular dysfunction. Cancer Tutor wanted to better understand, so we could share this information with our readers and we sat down with Al Sanchez, CEO of AMARC Enterprises and a member of the Foundation for Advancement in Cancer Research, to discuss all the buzz and benefits of Poly-MVA in the stand against cancer, degenerative disease, and better patient outcomes all around.
Click image to open pdf file : s20975.pcdn.co/wp-content/uploads/2018/08/LAMC.pdf
www.cancertutor.com/poly-mva/
Q: What is Poly-MVA?
Sanchez: Poly-MVA, its name is representative of what it is. Poly meaning multiple and the MVA standing for minerals, vitamins and amino acids. In the liquid solution that is Poly-MVA, you have multiple ingredients and a very unique complex, Lipoic Acid Mineral Complex (LAMC). Many think that POLY-MVA is just a mixture of certain ingredients. It is very different than just taking alpha lipoic acid and B-vitamins, for example. Taking ALA is great. Taking thiamine is great, taking B-2 and B-12 is great and fine. Even taking them together in a combination pill or mixture is great. However, taking them in Poly-MVA is vastly different. They go in as LAMC complex and they come out as that complex. They work in the body as this complex and unique bound molecule of lipoic acid and thiamin. They work at the mitochondria; the whole metabolic approach is enhanced because of this focus and target on metabolism. They can protect the cell on one side and support the cell energetically on the other side. It can protect and support at the same time because of the LAMC complex and is what is called a redox molecule, not because it's an individual ingredient.
Most supplements out there, as a matter of fact, I think almost all supplements out there, are at some level simply a mixture of ingredients or a concentration/combination of them. Let's say we're going to make a cake? You take all of the ingredients and you mix them up accordingly. The cake batter tastes really good and it tastes kind of similar to what the cake or final dessert is going to taste like when it comes out of the oven but it's not going to be exactly the same. Now all those ingredients are going to be in there once it's baked but now they're actually going to form new bonds, new connections and make something that didn't exist prior to it going in the oven. They have become complexed. All the other supplements out there are mixtures and concentrations of various ingredients; just like the batter we talked about, this is what really differentiates Poly-MVA from pretty much everything else out there. It is the cake; it is not the batter.
extensive info on website: www.cancertutor.com/poly-mva/
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Post by the Scribe on Jun 29, 2019 6:04:54 GMT -5
CANCER? I would consider this center or at least try to find an oncologist that uses the same methodology.www.nagourneycancerinstitute.com/We are Nagourney Cancer Institute, an accomplished cancer research and testing facility with a fully accredited federal and state licensed laboratory. For over 20 years, we've offered personalized cancer testing that helps select the most effective and least toxic drug regimen for your cancer. We also work with pharmaceutical and biotechnology firms to streamline their research and development process for bringing new compounds to market.
Our Founder and Medical Director: Robert Nagourney, MD
Dr. Robert Nagourney has been internationally recognized as a pioneer in cancer research and personalized cancer treatment for over 20 years.
Among his many accomplishments, as co-investigator on national cooperative trials, Dr. Nagourney is recognized for the introduction of Cisplatin/Gemcitabine doublets in the treatment of advanced ovarian and breast cancers.
He is the founder and medical director of Nagourney Cancer Institute (formerly Rational Therapeutics) and Clinical Professor at the University of California, Irvine School of Medicine.
Also, he is a practicing oncologist and triple board certified in Internal Medicine, Medical Oncology and Hematology.
With more than 20 years experience in human tumor primary culture analyses, Dr. Nagourney has authored more than 100 manuscripts, book chapters and abstracts including publications in the Journal of Clinical Oncology, Gynecologic Oncology, the Journal of the National Cancer Institute and British Journal of Cancer.
Click here to look at some of his published papers. www.nagourneycancerinstitute.com/published-papers
Dr. Nagourney has been a TEDx speaker and featured on radio, local and national television outlets such as CNN, ABC World News Tonight, CNBC, Extra, Hard Copy, Fox 11 Los Angeles, CBS2, KTLA5, ABC7, & KCAL9 (Los Angeles), WLWT5 & WCPO9 (Cincinnati), 13WHAM (Rochester, NY) and major newspapers such as the Wall Street Journal, Orange County Register, and Cincinnati Enquirer.
The most recent TV segment covering Dr. Nagourney's work was aired on December 2, 2018 by CBS 2 Los Angeles.
Click here to view this 3 minute TV segment about our work with a stage 4 cancer patient from Brazil. Her cancer cells tested sensitive to the common diabetes drug Metformin and this helped her make a dramatic recovery.
Dr. Nagourney has also been featured internationally such as on Australian TV show Good Medicine, and Univision's Primer Impacto.
Click here to see some of his talks.
In March 2013, his book Outliving Cancer was released by Basic Health Publications. Outliving Cancer is Dr. Nagourney's story of discovery, the biology of cancer and how best to treat it.
He has also served as a journal reviewer and on the editorial boards of several journals including Clinical Cancer Research, British Journal of Cancer, Gynecologic Oncology, Cancer Research and the Journal of Medicinal Food.
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Post by the Scribe on Jun 28, 2019 15:24:16 GMT -5
Higher Love ~ Whitney Houston Live
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Post by the Scribe on Jun 28, 2019 15:22:44 GMT -5
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Post by the Scribe on Jun 28, 2019 15:21:05 GMT -5
New Whitney Houston and Kygo collaboration 'Higher Love' is first new music released by her estateGood Morning America CHRISTOPHER WATSON Good Morning AmericaJune 28, 2019 www.yahoo.com/gma/whitney-houston-song-released-kygo-remixes-never-released-151824000--abc-news-celebrities.html
New Whitney Houston and Kygo collaboration 'Higher Love' is first new music released by her estate originally appeared on goodmorningamerica.com
Norwegian DJ and producer Kygo has taken a 30-year-old archival recording of Whitney Houston in her powerhouse prime, performing the 1986 Steve Winwood hit "Higher Love," and made it brand-new, with remastered vocals and a brand-new music track.
Houston's original performance was never officially released. It was a bonus track on the Japanese issue of her 1990 album "I'm Your Baby Tonight."
"I was honored when the Whitney Houston estate reached out and presented me with the opportunity to work with one of the greatest female vocalists of all time," said Kygo in a statement. "I reworked the song from scratch and am really happy with how it turned out!"
"The resurgence of this precious archival performance will carry Whitney's musical legacy on to a younger generation for years to come," Whitney's sister-in-law, Pat Houston, said in a statement. "A testament to Kygo's incredible talent, and a reminder of why we fell in love with Whitney from the very beginning!!!"
The world-renowned songstress died in 2012 at the age of 48 from accidental drowning due to atherosclerotic heart disease and cocaine use. Her death stunned the music world and fans across the globe.
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Post by the Scribe on Jun 28, 2019 2:31:29 GMT -5
I don’t think she was dating Jerry Brown when she was recording “You’re No Good”, I think she was with Albert Brooks. I remember an interview with Linda about the recording of YNG where she said Brooks made a comment about Andrew Gold and Peter Asher turning it into a Beatles song over night. Ronstadt and Brooks went back to the studio the next day to hear what Gold and Asher came up with the night before after she had gone home. Did you know Albert Brooks real name is Albert Einstein? So Linda actually dated Albert Einstein lol. They did date from 74 to 76 and it is said that Try Me Again is about Einstein. Possibly Jerry was the reason for the breakup if they were truly a thing at all? She met Jerry in 1971 and I believe it was an on and off thing so who knows? Maybe Linda can clarify for us.
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Post by the Scribe on Jun 27, 2019 15:33:30 GMT -5
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Post by the Scribe on Jun 27, 2019 12:36:52 GMT -5
Rick Shapiro will be interviewed on coasttocoastam radio tomorrow night 6/28/19 which is available in most markets or online too. www.coasttocoastam.com/ Cancer is not necessarily a death sentence. DON'T PANIC! Do like my mom often said "Don't fear it!" Calm down and approach it in a practical manner and look at your options. Easier said than done but highly doable but don't waste time thinking about it. First things first ...at least start with a healthy diet, cut out the sugar or sugar forming foods and other bad stuff while doing your investigation. That would be my first step and then go from there.Before you choose a cancer treatment, learn how late-stage and terminal patients beat the odds.
“Riveting and richly engrossing stories of courage … never say die.” —Dr. Oz, M.D., Host of Dr. Oz Show and Professor of Surgery, NYP Columbia Medical Center 20 POWERFUL, INSPIRATIONAL INTERVIEWS with late-stage and terminal cancer survivors, who are thriving 5, 10 and 20 plus years after receiving a dire prognosis, reveal how they beat the odds. EXCLUSIVE INTERVIEWS WITH RENOWNED CANCER SPECIALISTS illuminate their innovative, therapeutic paradigms that are saving lives now. These progressive icons are at the vanguard of cutting-edge cancer care. 83 CRITICAL QUESTIONS you MUST ask each of your cancer doctors before hiring them. INSIGHTFUL, INFORMATION-PACKED TESTIMONY of real hope, and news of life-saving, groundbreaking integrative and alternative treatments for cancer patients.Trailer for HOPE NEVER DIES by Rick ShapiroRick Shapiro Published on Aug 10, 2017 Hear and learn about HOPE NEVER DIES, Rick Shapiro’s new inspiring, ground-breaking book about 20 remarkable late-stage and terminal cancer survivors who beat the odds with evidence-based Integrative and alternative cancer therapies. HOPE NEVER DIES also includes exclusive interviews with 5 internationally-renowned cancer specialists who explain how their cutting-edge cancer therapies are saving lives, NOW. And, it includes a comprehensive set of critical questions you should ask your prospective cancer doctor before hiring him or her. On sale November 7, 2017. Preorder the book at www.HopeNeverDies.comInspiration for Hope Never Dies… I remember, distinctly, when my father died of cancer in 1996, his doctor said – “We look at your father’s situation as terminal.” Shocking, devastating words. I felt helpless. My father died 6 weeks later.
As time went on, I wondered why some people “beat the odds” and lived many years past their dire prognosis. My curiosity led me to engage in deep research to ascertain whether there were safe, effective, evidence-based medical treatments and therapies, beyond the strict “standard of care”, that can extend lives, save lives and enhance the quality of life for those who are told to “get their affairs in order”.
In recent years I have met, interviewed and befriended many hundreds of people, at over 20 cancer conferences, nationwide, who are living life and thriving many years, some for decades, past their so-called expiration dates.
I wish I knew then, at the time of my father’s illness, what I know now. My deep investigation and research has resulted in Hope Never Dies, a book that I hope will contribute to helping and saving the lives of many people afflicted with this insidious disease.
ABOUT THE AUTHOR Rick Shapiro, J.D., a former practicing attorney, is a leading consultant, researcher and educator in the field of safe, evidence-based, integrative and alternative cancer treatments. He has engaged in deep research about efficacious therapies that are extending and saving lives, and enhancing quality of life, beyond statistical norms generally found in the conventional cancer world.
He collaborates with internationally renowned doctors and researchers who are at the forefront of efficacious therapies. He has consulted with, and coached cancer patients from all over the world, including China, New Zealand, Okinawa, Europe, throughout the United States and in his hometown, Scottsdale, Arizona. The culmination of his work, developed after cancer took his father’s life over 20 years ago, is found in his book Hope Never Dies.hopeneverdies.com/blog/
www.youtube.com/playlist?list=PLN3M7esuvCerO_eJ0ykEaOElJmP1VZ-tV
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Post by the Scribe on Jun 26, 2019 15:35:27 GMT -5
The FM soundtrack was also a Universal release. The really sad thing about that is if there was FULL concert footage from the two days it was recorded that too may be lost. Linda was at the top of her game at that concert.
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Post by the Scribe on Jun 26, 2019 3:58:51 GMT -5
I am thinking Warner (Elektra Atlantic) Music Group owns the masters but many were remastered by Mobile Fidelity and they did such a great job that I am hoping they also have second generation copies. At least they may have some of them.
This reminds me of the time ABC trashed all of its In Concert videos because they ran out of storage space. Some great performances including Cat Stevens Moon and Star Concert which featured Linda Ronstadt as a special guest. What a shame. And the sad thing is that many of those aired before the masses had vcr recorders. Only selective few had them. And that particular concert had ABC and Dick Clark at odds with each other with both claiming rights but neither could prove who owned it. My niece who is in the "business" and does patents and copyrights in the industry had her friends at ABC do a search for me but it wasn't in their inventory or records. That means if there IS a copy that Dick Clark Productions might have it but I doubt it. The performance we see on youtube was posted by forum member Julian who bought it from a collector. I am thinking it is a copy unless the guy who sold it to him was a dumpster diver and grabbed as much as he could. We really lucked out that someone had that. It is probably my favorite live Linda segment.
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Post by the Scribe on Jun 25, 2019 11:30:40 GMT -5
I can't vouch for this product but the science is sound.Fig 1. Microcosm diagram of the mind by Robert Fludd.This Little-Known Brain Chemical is the Reason Why Your Memory Is Losing Its EdgeJune 23, 2019
It all started with minor slips you easily dismissed as "senior moments." You forgot your keys. You called someone by the wrong name. The word you were looking for was on the tip of your tongue, but you couldn't quite grasp it. You don't feel any older, but you do feel yourself changing. Researchers agree this could be a sign of something more serious.
A study published in the British Medical Journal of January 2012 has concluded that age-related cognitive decline begins much earlier than expected: by our mid-40s. Even more distressing, this decline can progress at very unpredictable rates. Scientists have identified that acetylcholine, a key neurotransmitter, is responsible for forming new connections and strengthening neural pathways in the brain. In other words, it keeps your mind sharp. However, persistently low levels of this key neurotransmitter places you at risk. Without healthy levels of acetylcholine, the brain can physically shrink; at which point, the damage can be very difficult to repair.
And yet, we all know people of advanced age who seem immune to this cognitive decline. These so-called superagers retain high mental acuity well into their later years. Scientists have determined that superagers minds' function with high levels of acetylcholine. Therefore, their minds have stronger and more numerous neural connections. This creates the ideal environment for a steel-trap memory. Unfortunately, for most of us, levels of acetylcholine decrease as we age and rapidly so after age 45.
But it's not just our age that is to blame. Like a muscle, your brain needs constant exercise to stay in shape. Modern society deprives us of essential mental exercise.
Before the written word became accessible and affordable, oral history was the only way to spread culture to younger generations. As a result, a strong memory was an essential part of everyday life. For example, ancient Greek poets would memorize and recite entire epic poems that were thousands of lines long. Because of the demands society placed on their brains, these individuals engaged in rigorous daily mental exercise. They did not have telephones, TVs, and computers distracting their attention and distorting the ways in which their brains processed information. This kind of singular focus required optimal levels of acetylcholine.
Fig 2. A network of neural connections in the brain.
Modern technology denies crucial exercise to certain areas of our brains in two important ways, causing it to atrophy over time. We are exposed to numerous sources of stimulation which constantly disrupt our production of acetylcholine. Likewise, we no longer need to remember phone numbers, addresses, dates, or even basic navigation because our phones have replaced our memories. Both of these factors train your mind to forget and place you at risk for earlier onset of cognitive decline.
In good news, new research says you don't need to throw away your smartphone, cancel your Netflix subscription, or quit your job to turn back the clock on age-related cognitive decline. A team of researchers in a GMP-certified laboratory in New York has identified 5 compounds that can naturally restore optimal levels of acetylcholine. They are Alpha GPC, Huperzine A, Bacopa Monnieri, Lion's Mane Mushroom, and Ginkgo Biloba. Better yet, clinically-backed by scientific research, these natural compounds do not contain exotic, unproven chemicals derived from marine life.
Over the last 18 months, this research team has combined these 5 safe and powerful natural compounds to boost levels of acetylcholine into one formula. It's called RediMind, and here's how it works.*
RediMind restores optimal levels of acetylcholine, protects you from age-related cognitive decline, and strengthens neural connections in the brain. The result? You can process and store information more easily and recall it much more quickly. RediMind gives you back the steel-trap memory of a confident mind.
To test the product's effectiveness, Princeton Consumer Research performed a placebo-controlled clinical trial in which the International Shopping List test was administered at different intervals at baseline, after 2 weeks, and after 30 days. The ISLT is a standardized short-term memory test consisting of a list of random grocery items which must be memorized and reproduced within a limited time frame.
Fig 3. The results of RediMind's placebo-controlled clinical study.
† Click here to view the complete results. www.princetonconsumer.com/wp-content/uploads/2018/04/NUTUSE4M-Final-Report-13Mar2018-signed2.pdf
While RediMind is not guaranteed to give you a photographic memory, the study boasts some impressive results. After 2 weeks, participants taking RediMind improved their memory score by over 45%. At the conclusion of the study, memory performance increased by over 51% and significantly outpaced placebo.†
RediMind is vegan, non-GMO, and gluten-free and is made in a GMP-certified facility in New York to ensure the highest standards of safety. The entire RediMind compound fits into one pill with low-dosage, high-efficiency ingredients for maximum effectiveness. Taken daily, RediMind improves confidence in relying your memory, as over 85% of study participants experienced. And unlike a shot of espresso, it does not give you a temporary boost followed by an energy crash. RediMind does not contain any caffeine, making it safe for long-term daily use.
Protect your mind today with RediMind to ensure a clear and confident future. This exclusive offer is not available in stores. It is only available online through June 27th. Click the link below to claim your 30 Day Trial of RediMind. www.nutreance.com/products/redimind
www.nutreance.com/articles/redimind?utm_medium=google_display&utm_campaign=redimind_us_custom_intent&utm_source=medicalxpress.com&utm_term=&gclid=EAIaIQobChMIs5TKkfCE4wIVVnhiCh3tQwrLEAEYASAAEgJgk_D_BwE
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Post by the Scribe on Jun 25, 2019 10:13:53 GMT -5
8 herbs and supplements for depressionLast updated Tue 26 February 2019 By Nicole Galan Reviewed by Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT
Depression is a serious mood disorder with symptoms that range from mild to debilitating and potentially life-threatening. Some people look to manage depression with herbal remedies, rather than with medication a doctor prescribes. The most recent data from the National Institute of Mental Health suggest that in the United States, 6.7 percent of people experienced a major depressive episode in 2016.
Medications and counseling are conventional ways to alleviate the symptoms of depression. However, some herbs and supplements may also help.
In this article, we look at the common herbs and supplements with links to the treatment of depression and discuss their safety and effectiveness.
Some herbs, essential oils, and supplements have shown promising effects for people with depression. The use of complementary therapies continues to gain popularity, as people look for more natural methods of managing their health.
However, herbal does not always mean safe or effective, and knowing which products to choose can save a lot of time and money.
In the United States, the Food and Drug Administration (FDA) do not monitor herbs in the same way as food and drugs. As a result, manufacturers are not always 100 percent clear about the quality or purity of their product.
Research suggests promise for some supplements in treating mild-to-moderate depression. These are some of the supplements that people most widely use:
www.medicalnewstoday.com/articles/314421.php
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Post by the Scribe on Jun 25, 2019 9:44:31 GMT -5
ALERTJUNE 24, 2019Commonly prescribed drugs could increase the risk of dementia, says a new studyby University of Nottingham
The study, carried out by experts from the University of Nottingham and funded by the NIHR School for Primary Care Research, found that there was nearly a 50% increased risk of dementia among patients aged 55 and over who had used strong anticholinergic medication daily for three years or more.
Anticholinergic drugs help to contract and relax muscles. They work by blocking acetylcholine, a chemical that transmits messages in the nervous system.
Doctors prescribe the drugs to treat a variety of conditions, including chronic obstructive pulmonary disease, bladder conditions, allergies, gastrointestinal disorders and symptoms of Parkinson's disease. These medicines can have short-term side effects, including confusion and memory loss, but it is less certain whether long-term use increases the risk of dementia.
The research, published in the JAMA Internal Medicine journal and led by Professor Carol Coupland from the University's Division of Primary Care, looked at the medical records of 58,769 patients with a diagnosis of dementia and 225,574 patients without a diagnosis of dementia, all aged 55 and over and registered with UK GPs contributing data to the QResearch database, between 1 January 2004 and 31 January 2016.
The study findings showed increased risks of dementia for anticholinergic drugs overall and specifically for the anticholinergic antidepressants, antipsychotic drugs, antiparkinsons drugs, bladder drugs and epilepsy drugs after accounting for other risk factors for dementia.
No increased risks were found for the other types of anticholinergic drug studied such as antihistamines and gastrointestinal drugs.
Professor Tom Dening, Head of the Centre for Dementia at the University of Nottingham and a member of the research study team, said: "This study provides further evidence that doctors should be careful when prescribing certain drugs that have anticholinergic properties. However, it's important that patients taking medications of this kind don't just stop them abruptly as this may be much more harmful. If patients have concerns, then they should discuss them with their doctor to consider the pros and cons of the treatment they are receiving."
The 58,769 patients with dementia had an average age of 82 and 63% were women. Each dementia case was matched to five control patients of the same age, sex, and general practice.
Anticholinergic drug exposure was assessed using prescription information over a complete period of 10 years from 1 to 11 years before diagnosis of dementia or the equivalent dates in control patients, and was compared between the two patient groups. Further analysis looked at prescriptions for anticholinergic drugs up to 20 years before diagnosis of dementia.
This is an observational study so no firm conclusions can be drawn about whether these anticholinergic drugs cause dementia, and it is possible that the drugs were being prescribed for very early symptoms of dementia.
Professor Coupland said: "Our study adds further evidence of the potential risks associated with strong anticholinergic drugs, particularly antidepressants, bladder antimuscarinic drugs, anti-Parkinson drugs and epilepsy drugs.
"The risks of this type of medication should be carefully considered by healthcare professionals alongside the benefits when the drugs are prescribed and alternative treatments should be considered where possible, such as other types of antidepressants or alternative types of treatment for bladder conditions. These findings also highlight the importance of carrying out regular medication reviews.
"We found a greater risk for people diagnosed with dementia before the age of 80 which indicates that anticholinergic drugs should be prescribed with caution in middle-aged people as well as in older people."
These results, along with those of a similar study published in 2018 help to clarify which types of anticholinergic drug are associated with the highest risks of dementia.
In the 1-11 years before the dementia diagnosis date or equivalent in controls, nearly 57% of cases and 51% of controls were prescribed at least one strong anticholinergic drug, with an average of six prescriptions in cases and 4 in controls. The most frequently-prescribed types of drugs were antidepressants, anti-vertigo and bladder antimuscarinic drugs—which are used to treat an overactive bladder.
The increased risk associated with these drugs indicates that if the association is causal around 10% of dementia diagnoses could be attributable to anticholinergicdrug exposure, which would equate to around 20,000 of the 209,600 new cases of dementia per year in the UK.
This is a sizeable proportion and is comparable with other modifiable risk factors for dementia, including 5% for midlife hypertension, 3% for diabetes, 14% for later life smoking and 6.5% for physical inactivity.
medicalxpress.com/news/2019-06-commonly-drugs-dementia.html
LIST OF OTHER DRUGS
www.theseniorlist.com/medication/anticholinergic-drugs/
www.medicalnewstoday.com/articles/325553.php?utm_source=TrendMD&utm_medium=cpc&utm_campaign=Medical_News_Today_TrendMD_1
medicalxpress.com/news/2018-04-common-class-drugs-linked-dementia.html
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